L-5-MTHF-Ca Cas No.151533-22-1

L-5-methyltetrahydrofolate calcium (5-MTHF) is a salt-forming methyl derivative naturally produced by folic acid. 

5-MTHF is also known as L-methylfolate. Form, easier to absorb than ordinary folic acid. 

There are two main metabolic pathways that ordinary folic acid must be converted to L-methyl folic acid: 

methylation process and DNA synthesis. 

The only form of free folic acid usually present in human plasma and cells is 5-MTHF.

Function & Application:

1. Supplement folic acid level to prevent megaloblastic anemia and leukopenia.

2. Prevent neural tube malformation, cleft lip and palate, congenital heart disease and other birth defects.

3. Improve body immunity.

4. Anti-tumor and anticancer effects. Naturally occurring active folic acid can cause apoptosis of cancer cells, have a certain effect on gene expression of cancer cells, 

and prevent esophageal cancer, colorectal cancer and other cancers.

5. Reduce homocysteine level, protect cardiovascular and cerebrovascular diseases, prevent stroke, coronary heart disease 

and other cardiovascular and cerebrovascular diseases.

6. Protect cognitive function and help prevent dementia and Alzheimer's.

7. Prevent depression. Helps neurotransmitter synthesis, regulates mood.

8. Prevent chronic kidney disease, atrophic gastritis and other chronic diseases.

9. Prevent alcohol-induced liver injury and osteoporosis.

Compared with synthetic folic acid

(1) Safety: 

Naturally active folic acid is an endogenous basic substance of the human body, 

and will not cause adverse reactions such as allergies.

(2) Effectiveness: 

Naturalized active FOLIC ACID is superior to synthetic inactive folic acid in terms of effectiveness, 

because synthetic inactive folic acid cannot be directly absorbed and utilized. 

During intestinal absorption and transport to peripheral tissues, synthetic folate is reduced to dihydrofolate by dihydrofolate reductase. 

Dihydrofolate is further reduced by dihydrofolate reductase to tetrahydrofolate; 

Tetrahydrofolate is then converted to 5, 10-methylenetetrahydrofolate; 5, 10-methylenetetrahydrofolate finally forms 6S-5-methylenetetrahydrofolate under the catalysis of methylenetetrahydrofolate reductase (MTHFR), which is involved in two key metabolic pathways: methylation process and DNA synthesis. 

Through the above metabolic process, inactive synthetic folic acid can be converted into biologically active 5-methyltetrahydrofolic acid.However, due to the gene mutation of this key metabolic enzyme, its genotype is different, and the ability of some people to convert inactive synthetic folic acid into active folic acid is reduced, resulting in folic acid metabolism disorders, affecting the normal biological effects of folic acid in the body. 

Naturally occurring active folic acid is not affected by the conversion of folic acid metabolic enzymes, and can be directly absorbed and utilized by all people, 

and is not restricted by race and region. 

Therefore, for people with folic acid metabolism disorders, naturally occurring active folic acid has a wider range of effectiveness 

and is a better choice for folic acid supplementation.

(3) Dose assurance: 

The amount of active folic acid that can be obtained through synthetic folic acid conversion in the body is limited and varies by population (genotype). 

The direct intake of naturally active folic acid does not exist in the body conversion link, 

which can ensure that the intake dose is quickly absorbed to obtain the required accurate dose.

Summary: 

Folate-rich animal and plant foods are the best source of folic acid and are the first choice for folic acid supplementation. 

The cooking process of foods containing folic acid should avoid excessive acid and alkali and prolonged heat to protect folic acid from being destroyed as much as possible. 

Pregnant women and children at the stage of rapid development have a large need for folic acid 

and need to take folic acid supplements to make up for the deficiency of folic acid in food. 

Synthetic folic acid is cheap but needs to be metabolized first, and humans have limited benefits from it, but also face the safety risks of residual folic acid.

 Active folic acid is folic acid that can be directly absorbed and utilized, bypassing the metabolic link to solve these problems, 

but due to the high content of impurities, the use of raw materials with safety risks is not safe for the fetus. Natural active folic acid leaf source acid is highly pure, intrinsically safe, 

is an upgrade of active folic acid. China was the first country in the world to approve the listing of natural active folic acid, 

achieving a corner overtaking in the field of folic acid. Due to technical and cost issues, 

naturally extracted folic acid products do not exist. Claims of natural folic acid, fruit and vegetable folic acid are just a commercial gimmick.